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A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma

This review aims to summarize the putative role of histone deacetylases (HDACs) in rhabdomyosarcoma (RMS) and the effects of HDAC inhibitors (HDACi) on RMS by elucidating and highlighting known oncogenic pathways, mechanisms of resistance, and the synergistic potential of histone deacetylase inhibit...

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Principais autores: Omar Selim, Clara Song, Amy Kumar, Rebecca Phelan, Arun Singh, Noah Federman
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-08-01
coleção:Frontiers in Oncology
Assuntos:
rhabdomyosarcoma
histone deacetylase inhibitors
pediatric cancer
clinical trials
mutations
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fonc.2023.1244035/full
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