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Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis by oxylanosterols.

Treatment of rat intestinal epithelial cell cultures with the oxidosqualene cyclase inhibitor, 3 beta-[2-(diethylamino)-ethoxy]androst-5-en-17-one (U18666A), resulted in an accumulation of squalene 2,3:22,23-dioxide (SDO). When U18666A was withdrawn and the cells were treated with the sterol 14 alph...

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Detalhes bibliográficos
Principais autores: S R Panini, R C Sexton, A K Gupta, E J Parish, S Chitrakorn, H Rudney
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 1990-05-01
coleção:Journal of Lipid Research
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0022227520387551
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