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CD14 Blockade Modulates Macrophage-Mediated Immunological Injury in a Translational Model of Reperfused ST-Segment Elevation Myocardial Infarction

Summary: These preclinical trials provide the first evidence of cluster of differentiation 14 (CD14) blockade with a murine analogue of atibuclimab, a CD14-neutralizing antibody, preventing secondary immunological exacerbation of cardiac injury in a translational mouse model of reperfused ST-segment...

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Kaydedildi:
Asıl Yazarlar: Aascha A. D’Elia (nee Brown), PhD, Helen Kiriazis, PhD, Jason Bloom, MD, Jonathan Noonan, PhD, Ian Hsu, PhD, Gabriella E. Farrugia, PhD, Haoyun Fang, PhD, Stephanie Jansen, BVetSc, Natalia Carvajal, PhD, Crisdion Krstevski, PhD, Waled A. Shihata, PhD, Yow Keat Tham, PhD, Angela Vais, PhD, Camilla Cohen, PhD, Adam C. Parslow, PhD, Chad Johnson, PhD, Anita C. Thomas, PhD, Malathi S.I. Dona, PhD, Kyah Grigolon, BVetSc, Scott J.Y. Loh, BSc (Hons), Guy Krippner, PhD, David K. Wright, PhD, Bing H. Wang, PhD, Antonio Abbate, MD, PhD, Junedh Amrute, PhD, Kory Lavine, MD, PhD, Mark W. Appleby, PhD, David Crowe, PhD, Garry Redlich, DUniv, Brian W. Ziegelaar, PhD, Julie R. McMullen, PhD, David W. Greening, PhD, Alexander R. Pinto, PhD, David M. Kaye, MD, PhD, Daniel G. Donner, PhD
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier 2025-11-01
Seri Bilgileri:JACC: Basic to Translational Science
Konular:
antibody therapy
CD14
heart failure
immunomodulation
myocardial infarction
Online Erişim:http://www.sciencedirect.com/science/article/pii/S2452302X25003468
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