Megakaryocytes transfer mitochondria to bone marrow mesenchymal stromal cells to lower platelet activation

Newly produced platelets acquire a low activation state, but whether the megakaryocyte plays a role in this outcome has not been fully uncovered. Mesenchymal stem cells (MSCs) were previously shown to promote platelet production and lower platelet activation. We found that healthy megakaryocytes tra...

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Detalhes bibliográficos

Principais autores:	Chengjie Gao, Yitian Dai, Paul A. Spezza, Paul Boasiako, Alice Tang, Giselle Rasquinha, Hui Zhong, Bojing Shao, Yunfeng Liu, Patricia A. Shi, Cheryl A. Lobo, Xiuli An, Anqi Guo, William B. Mitchell, Deepa Manwani, Karina Yazdanbakhsh, Avital Mendelson
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2025-04-01
coleção:	The Journal of Clinical Investigation
Assuntos:	Hematology Stem cells
Acesso em linha:	https://doi.org/10.1172/JCI189801
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