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Tropoxine in the effective dose does not affect on activity of CYP2С9 and CYP1А2 isoforms of cytochrome P450 in rats

Effects of tropoxine on activity of isoforms CYP2С9 and CYP2С9 of cytochrome P450 using marker drugs losartane and caffeine were studied. Tropoxine in the effective dose (30 mg/kg) after 4-days intraperitoneal administration (3 times per day) in rats did not produce changes of CYP2C9 and CYP1A2 isof...

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Principais autores: V. P. Zherdev, G. B. Kolyvanov, A. A. Litvin, O. G. Grybakina, P. O. Bochkov, R. V. Shevchenko
Format: Artigo
Sprog:Russo
Udgivet: LLC “Publisher OKI” 2017-11-01
Serier:Фармакокинетика и Фармакодинамика
Fag:
тропоксин
cyp2с9
cyp1а2
лозартан
кофеин
метаболическое отношение
межлекарственное взаимодействие
tropoxine
cyp1a2
losartane
caffeine
metabolic ratio
drug-drug interaction
Online adgang:https://www.pharmacokinetica.ru/jour/article/view/39
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