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IL-17A and TNF-α inhibitors induce multiple molecular changes in psoriasis

Adalimumab and secukinumab are commonly used for moderate to severe psoriasis vulgaris (PV). Although distinct individual responses to and impaired effectiveness of these biological agents occur occasionally, little is known about the underlying reasons. Here, we report a proteomic analysis of psori...

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Principais autores: Qiang Dong, Dan Li, Bi Bo Xie, Li Hua Hu, Jia Huang, Xiao Xiao Jia, Yan Li Tang, Gan Hong Liu, Ning Ning Shen, Xiao Bing Yu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-11-01
Serier:Frontiers in Immunology
Fag:
proteomics
psoriasis
parallel reaction monitoring
data-independent acquisition mass spectrometry
biological agent
ingenuity pathway analysis
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1015182/full
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