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Roles of RAGE/ROCK1 Pathway in HMGB1-Induced Early Changes in Barrier Permeability of Human Pulmonary Microvascular Endothelial Cell

BackgroundHigh mobility group box 1 (HMGB1) causes microvascular endothelial cell barrier dysfunction during acute lung injury (ALI) in sepsis, but the mechanisms have not been well understood. We studied the roles of RAGE and Rho kinase 1 (ROCK1) in HMGB1-induced human pulmonary endothelial barrier...

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Principais autores: Meng-jiao Zhao, Hao-ran Jiang, Jing-wen Sun, Zi-ang Wang, Bo Hu, Cheng-rui Zhu, Xiao-han Yin, Ming-ming Chen, Xiao-chun Ma, Wei-dong Zhao, Zheng-gang Luan
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Assuntos:
endothelium
high mobility group box 1
barrier permeability
signaling
inflammation
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2021.697071/full
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