Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design1

Rapidly multiplying cancer cells synthesize greater amounts of cholesterol to build their membranes. Cholesterol-lowering drugs (statins) are currently in clinical trials for anticancer chemotherapy. However, given at higher doses, statins cause serious side effects by inhibiting the formation of ot...

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Bibliografiske detaljer

Principais autores:	Tatiana Y. Hargrove, Laura Friggeri, Zdzislaw Wawrzak, Suneethi Sivakumaran, Eugenia M. Yazlovitskaya, Scott W. Hiebert, F. Peter Guengerich, Michael R. Waterman, Galina I. Lepesheva
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2016-08-01
Serier:	Journal of Lipid Research
Fag:	cancer cholesterol cholesterol/biosynthesis enzymology/enzyme mechanisms membranes X-ray crystallography
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0022227520352251
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