Synthesis of 2’-Modified Nucleotides
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with poten...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI AG
2000-05-01
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| Serier: | Molecules |
| Fag: | |
| Online adgang: | http://www.mdpi.com/1420-3049/5/5/727/ |
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