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Reactive oxygen species‐responsive mitochondria‐targeted liposomal quercetin attenuates retinal ischemia–reperfusion injury via regulating SIRT1/FOXO3A and p38 MAPK signaling pathways

Abstract Retinal ischemia–reperfusion (RIR) injury is involved in the pathogenesis of various vision‐threatening diseases. The overproduction of reactive oxygen species (ROS) is thought to be the main cause of RIR injury. A variety of natural products, including quercetin (Que), exhibit potent antio...

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Principais autores: Laien Zhao, Longbing Ling, Jing Lu, Feng Jiang, Jianchao Sun, Zhen Zhang, Yanmei Huang, Xiaoqian Liu, Yanjuan Zhu, Xiaoxuan Fu, Shengjun Peng, Wenze Yuan, Ruikang Zhao, Zhuhong Zhang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2023-05-01
Serier:Bioengineering & Translational Medicine
Fag:
FOXO3A
mitochondria targeted
quercetin
retinal ischemia–reperfusion injury
ROS‐responsive liposomes
Online adgang:https://doi.org/10.1002/btm2.10460
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