Dimethyl α-ketoglutarate ameliorates cisplatin-induced acute kidney injury by modulating mitophagy through the PINK1/Parkin pathway

Abstract Background Mitochondrial dysfunction and abnormal energy metabolism are key determinants of the progression of acute kidney injury (AKI). α-Ketoglutarate (AKG) is an intermediate metabolite of the tricarboxylic acid cycle and plays a crucial role in energy metabolism and amino acid synthesi...

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Autores principales:	Haijing Dou, Huihui Hao, Ruoyi Zhao, Hailun Li, Fangshu Wei, Yong Xu, Donghui Zheng, Juan Xie, Xiang Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	European Journal of Medical Research
Materias:	Alpha-ketoglutarate Mitophagy Cisplatin Acute kidney injury Network pharmacology
Acceso en línea:	https://doi.org/10.1186/s40001-025-03010-7
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