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Effects of treatment with a carbon monoxide donor and an activator of heme oxygenase 1 on the nociceptive, apoptotic and/or oxidative alterations induced by persistent inflammatory pain in the central nervous system of mice

The activation of heme oxygenase 1 (HO-1)/carbon monoxide (CO) inhibits chronic inflammatory pain, but its role in the central nervous system (CNS) is not entirely known. We evaluated whether the treatment with an HO-1 inducer, cobalt protoporphyrin IX (CoPP), or a CO-releasing molecule, tricarbonyl...

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Hoofdauteurs: Rafael A. Cazuza, Gerard Batallé, Xue Bai, Christie R.A. Leite-Panissi, Olga Pol
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2022-10-01
Reeks:Brain Research Bulletin
Onderwerpen:
Apoptosis
Carbon monoxide
Heme oxygenase
Inflammatory pain
Nociception
Oxidative stress
Online toegang:http://www.sciencedirect.com/science/article/pii/S0361923022001952
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