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Process Optimization of Novel Boronophenylalanine Liposomes Through Box–Behnken Response Surface Design and Preliminary Evaluation in A549 Lung Carcinoma Cells for Boron Neutron Capture Therapy

Boron neutron capture therapy (BNCT) is a binary targeted radiotherapy that uses boron agents to treat refractory malignancies. This study developed a novel boronophenylalanine (BPA)-loaded liposome doped with o-carborane (CB) for BNCT. We applied response surface methodology (RSM) to identify facto...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Haojie Shi, Qianlong Xu, Fenglin Li, Caiyun Fan, Yi Han
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2026-04-01
Schriftenreihe:Molecules
Schlagworte:
CB-BPA-Lips
liposome
BNCT
BPA
o-carborane
BBD-RSM
Online-Zugang:https://www.mdpi.com/1420-3049/31/9/1409
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