Kappa free light chains in cerebrospinal fluid to detect inflammation - results from a multicentric prospective real-world study

BackgroundFree light chain kappa (FLCκ) have emerged as a sensitive biomarker to detect intrathecal immunoglobulin synthesis. To evaluate the role of FLCκ in routine cerebrospinal fluid laboratory diagnostics we conducted a prospective nationwide real world diagnostic study for evaluating the integr...

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Autori principali:	Marie Süße, Malte Johannes Hannich, Felix Lottermoser, Stefan Gross, Kathrin Budde, Irena Crnkovic-Mertens, Margot Thiaucourt, Markus Roser, Franz Felix Konen, Thomas Skripuletz, Rayan Suliman, Peter Mirtschink, Henry Bock, Karl Reuner, David Poitz, Tjalf Ziemssen, Hayrettin Tumani, Jan Lewerenz, Michael Khalil, Andrea Harrer, Matthias Nauck, Alexander Dressel
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-03-01
Serie:	Frontiers in Immunology
Soggetti:	cerebrospinal fluid free light chain kappa intrathecal immunoglobulin synthesis oligoclonal IgG FLCk synthesis
Accesso online:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1806398/full
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