WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

The dysregulation of transcription factors is widely associated with tumorigenesis. As the most well-defined transcription factor in multiple types of cancer, c-Myc can transform cells by transactivating various downstream genes. Given that there is no effective way to directly inhibit c-Myc, c-Myc...

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Váldodahkkit:	Xiaomeng Gao, Jieqiong You, Yanling Gong, Meng Yuan, Haiying Zhu, Liang Fang, Hong Zhu, Meidan Ying, Qiaojun He, Bo Yang, Ji Cao
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Elsevier 2022-03-01
Ráidu:	Acta Pharmaceutica Sinica B
Fáttát:	Transcription factors c-Myc WSB1 Ubiquitination-proteasome pathway β-Catenin destruction complex Feedback loop
Liŋkkat:	http://www.sciencedirect.com/science/article/pii/S221138352100424X
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