Metabolic Reprogramming of Glioblastoma Cells during HCMV Infection Induces Secretome-Mediated Paracrine Effects in the Microenvironment

Glioblastoma (GBM) is an aggressive primary central nervous system neoplasia with limited therapeutic options and poor prognosis. Following reports of cytomegalovirus (HCMV) in GBM tumors, the anti-viral drug Valganciclovir was administered and found to significantly increase the longevity of GBM pa...

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Autors principals:	Mark A. A. Harrison, Emily M. Hochreiner, Brooke P. Benjamin, Sean E. Lawler, Kevin J. Zwezdaryk
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2022-01-01
Col·lecció:	Viruses
Matèries:	human cytomegalovirus (HCMV) glioblastoma (GBM) metabolism aerobic glycolysis oxidative phosphorylation (OXPHOS) lactate
Accés en línia:	https://www.mdpi.com/1999-4915/14/1/103
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