Knockout of signal peptide peptidase in the eye reduces HSV-1 replication and eye disease in ocularly infected mice.
We previously reported that knocking out signal peptide peptidase (SPP), a glycoprotein K (gK) binding partner, in mouse peripheral sensory neurons reduced latency-reactivation in infected mice without affecting primary virus replication or eye disease. Since virus replication in the eye plays an es...
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| Principais autores: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Public Library of Science (PLoS)
2022-10-01
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| 叢編: | PLoS Pathogens |
| 在線閱讀: | https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010898&type=printable |
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