Receptor editing constrains development of phosphatidyl choline-specific B cells in VH12-transgenic mice

Summary: B1 B cells reactive to phosphatidyl choline (PtC) exhibit restricted immunoglobulin heavy chain (HC) and light chain (LC) combinations, exemplified by VH12/Vκ4/5H. Two checkpoints are thought to focus PtC+ B cell maturation in VH12-transgenic mice (VH12 mice): V-J rearrangements encoding a...

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Auteurs principaux:	Alexandra N. Worth, Victoria L. Palmer, N. Max Schabla, Greg A. Perry, Anna N. Fraser-Philbin, Patrick C. Swanson
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2022-06-01
Collection:	Cell Reports
Sujets:	CP: Immunology
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S221112472200674X
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