Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex

<p>Abstract</p> <p>Background</p> <p>The positive transcription elongation factor, P-TEFb, comprised of cyclin dependent kinase 9 (Cdk9) and cyclin T1, T2 or K regulates the productive elongation phase of RNA polymerase II (Pol II) dependent transcription of cellular and integrated viral genes. P-TE...

全面介紹

書目詳細資料

Principais autores:	Nguyen Van Trung, Price Jason P, Byers Sarah A, Biglione Sebastian, Bensaude Olivier, Price David H, Maury Wendy
格式:	Artigo
語言:	Inglês
出版:	BMC 2007-07-01
叢編:	Retrovirology
在線閱讀:	http://www.retrovirology.com/content/4/1/47
標簽:	添加標簽 沒有標簽, 成為第一個標記此記錄!