Synthesis of medronic acid monoesters and their purification by high-performance countercurrent chromatography or by hydroxyapatite

We achieved the synthesis of important medronic acid monoalkyl esters via the dealkylation of mixed trimethyl monoalkyl esters of medronic acid. Two methods were developed for the purification of medronic acid monoesters: 1) small scale (10–20 mg) purification by using hydroxyapatite and 2) large sc...

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Hauptverfasser:	Elina Puljula, Jouko Vepsäläinen, Petri A. Turhanen
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Beilstein-Institut 2016-10-01
Schriftenreihe:	Beilstein Journal of Organic Chemistry
Schlagworte:	bisphosphonate bisphosphonate monoester high performance counter current chromatography hydroxyapatite medronic acid
Online-Zugang:	https://doi.org/10.3762/bjoc.12.204
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