Design, Synthesis and Cellular Characterization of a Dual Inhibitor of 5-Lipoxygenase and Soluble Epoxide Hydrolase

The arachidonic acid cascade is a key player in inflammation, and numerous well-established drugs interfere with this pathway. Previous studies have suggested that simultaneous inhibition of 5-lipoxygenase (5-LO) and soluble epoxide hydrolase (sEH) results in synergistic anti-inflammatory effects. I...

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Principais autores:	Karin Meirer, Daniel Glatzel, Simon Kretschmer, Sandra K. Wittmann, Markus Hartmann, René Blöcher, Carlo Angioni, Gerd Geisslinger, Dieter Steinhilber, Bettina Hofmann, Robert Fürst, Ewgenij Proschak
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2016-12-01
coleção:	Molecules
Assuntos:	soluble epoxide hydrolase 5-lipoxygenase inflammation designed multitarget ligands leukocyte-endothelial cell interaction
Acesso em linha:	http://www.mdpi.com/1420-3049/22/1/45
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