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Therapeutic drug monitoring-guided dosing of busulfan differs from weight-based dosing in hematopoietic stem cell transplant patients

Busulfan (Bu)-based preparative regimens in hematopoietic stem cell transplantation are commonly used. Previous studies have shown that Bu at a fixed dose of 3.2 mg/kg/day (FBD) given intravenously decreases variability in drug pharmacokinetics and this decreases the dependency on therapeutic drug m...

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Hoofdauteurs: Bushra Salman, Mohammed Al-Za’abi, Mohammed Al-Huneini, David Dennison, Abdulhakeem Al-Rawas, Salam Al-Kindi, Khalil Al-Farsi, Melanie Tauro, Murtadha Al-Khabori
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Wolters Kluwer Medknow Publications 2017-04-01
Reeks:Hematology/Oncology and Stem Cell Therapy
Onderwerpen:
busulfan
pharmacokinetics
drug monitoring
hematopoietic stem cell transplantation
Online toegang:https://journals.lww.com/10.1016/j.hemonc.2017.03.003
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