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Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4

Abstract Background Hypertension (HTN) has been linked to changes in DNA methylation. However, longitudinal epigenome-wide analyses are still limited. Methods We analyzed data from the KORA F4 and FF4 studies, conducted approximately 7 years apart. The dataset included 2614 participants, each with D...

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Principais autores: Liye Lai, Angelina Shin Yee Jong, Thomas Delerue, Jiesheng Lin, Barbara Thorand, Margit Heier, Holger Prokisch, Aiman Farzeen, Juliane Winkelmann, Elisabeth Thiering, Christian Gieger, Annette Peters, Melanie Waldenberger
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2026-02-01
Series:BMC Medicine
Assuntos:
DNA methylation
Hypertension
Blood pressure
Methylation trajectory
Gene expression
Acceso en liña:https://doi.org/10.1186/s12916-026-04672-8
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