Sex differences in cardiac graft recovery and pathophysiologic changes in a rat model of donation after circulatory death

Abstract Biological sex affects cardiac tolerance to ischemia and reperfusion, but little is known about sex differences in heart transplantation with donation after circulatory death (DCD). Using a rat model, we characterized differences between sexes both in the donor, during simulated DCD, and in...

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Autors principals:	Alexia Clavier, Selianne Graf, Anja Helmer, Deborah Lagger, Manuel Egle, Adrian Segiser, Matthias Siepe, Maria Arnold, Sarah Longnus
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-11-01
Col·lecció:	Scientific Reports
Matèries:	Sex as a biological variable (SABV) Heart transplantation Donation after circulatory death (DCD) Cardiac ischemia/reperfusion injury Ex-situ/ex-vivo heart perfusion
Accés en línia:	https://doi.org/10.1038/s41598-025-28644-9
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