Recombinant human melatonin receptor MT1 isolated in mixed detergents shows pharmacology similar to that in mammalian cell membranes.

The human melatonin MT1 receptor-belonging to the large family of G protein-coupled receptors (GPCRs)-plays a key role in circadian rhythm regulation and is notably involved in sleep disorders and depression. Structural and functional information at the molecular level are highly desired for fine ch...

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Hauptverfasser:	Christel Logez, Sylvie Berger, Céline Legros, Jean-Louis Banères, William Cohen, Philippe Delagrange, Olivier Nosjean, Jean A Boutin, Gilles Ferry, Frédéric Simonin, Renaud Wagner
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Public Library of Science (PLoS) 2014-01-01
Schriftenreihe:	PLoS ONE
Online-Zugang:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24959712/pdf/?tool=EBI
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