Association between plasma glucosylsphingosine levels and dyskinesia burden in GBA1-related Parkinson's disease

Background: GBA1 mutation is the most significant genetic risk factor for Parkinson's disease (PD). It encodes glucocerebrosidase (GCase), whose dysfunction – seen in Gaucher disease - leads to the accumulation of glucosylceramide and its derivate glucosylsphingosine (GlcSph). However, it remains un...

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Autors principals:	Massimo Marano, Carmela Zizzo, Francesco Cavallieri, Micol Avenali, Tommaso Schirinzi, Edoardo Monfrini, Francesca Spagnolo, Rosa De Micco, Silvia Ramat, Maria Chiara Malaguti, Federico Reali, Roberto Cilia, Miryam Carecchio, Andrea Pilotto, Roberto Erro, Ilaria Antonella di Vico, Mario Meloni, Giulia Di Lazzaro, Sara Pietracupa, Claudia Ledda, Giovanni Mostile, Marcello Mario Mascia, Valentina Fioravanti, Giulia di Rauso, Roberta Bovenzi, Simone Aloisio, Marco Liccari, Ruggero Bacchin, Fabiana Colucci, Giulia Bonato, Alessandro Lupini, Alessandro Magliozzi, Cristiano Sorrentino, Francesca Leo, Giulia Franco, Nicola Modugno, Maurizio Zibetti, Gennarina Arabia, Anna Rita Bentivoglio, Elena Caputo, Filippo Tamma, Alessandro Padovani, Mario Zappia, Roberto Eleopra, Michele Tinazzi, Giovanni Fabbrini, Alessandro Tessitore, Vincenzo Di Lazzaro, Enza Maria Valente, Giovanni Duro, Alessio Di Fonzo
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2026-02-01
Col·lecció:	Neurobiology of Disease
Matèries:	Glucosylsphingosine Glucocerebrosidase Parkinson's disease Dyskinesias Motor fluctuations
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S096999612600015X
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