Overexpressed NaV1.7 Channels Confer Hyperexcitability to in vitro Trigeminal Sensory Neurons of CaV2.1 Mutant Hemiplegic Migraine Mice

Trigeminal sensory neurons of transgenic knock-in (KI) mice expressing the R192Q missense mutation in the α1A subunit of neuronal voltage-gated CaV2.1 Ca2+ channels, which leads to familial hemiplegic migraine type 1 (FHM1) in patients, exhibit a hyperexcitability phenotype. Here, we show that the e...

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Detalhes bibliográficos

Principais autores:	Riffat Mehboob, Anna Marchenkova, Arn M. J. M. van den Maagdenberg, Andrea Nistri
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-05-01
coleção:	Frontiers in Cellular Neuroscience
Assuntos:	sodium channel calcium channel nociception migraine purinergic receptors transgenic mice
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fncel.2021.640709/full
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