Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

TET1/2/3 are methylcytosine dioxygenases that regulate cytosine hydroxymethylation. Tet1/2 are abundantly expressed in HSC/HPCs and are implicated in hematological malignancies. Tet2 deletion in mice causes myeloid malignancies, while Tet1-null mice develop B cell lymphoma after an extended period o...

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Detaylı Bibliyografya
Asıl Yazarlar:	Zhigang Zhao, Li Chen, Meelad M. Dawlaty, Feng Pan, Ophelia Weeks, Yuan Zhou, Zeng Cao, Hui Shi, Jiapeng Wang, Li Lin, Shi Chen, Weiping Yuan, Zhaohui Qin, Hongyu Ni, Stephen D. Nimer, Feng-Chun Yang, Rudolf Jaenisch, Peng Jin, Mingjiang Xu
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Elsevier 2015-11-01
Seri Bilgileri:	Cell Reports
Online Erişim:	http://www.sciencedirect.com/science/article/pii/S2211124715012073
Etiketler:	Etiketle Etiket eklenmemiş, İlk siz ekleyin!

Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice

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