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MIG-6 suppresses endometrial epithelial cell proliferation by inhibiting phospho-AKT

Abstract Background Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone (P4) inhibits proliferation by coordinating stromal-epithelial cross-ta...

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Principais autores: Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi, Tae Hoon Kim
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-05-01
Serier:BMC Cancer
Fag:
MIG-6
Progesterone resistance
Endometrial hyperplasia
AKT
Online adgang:http://link.springer.com/article/10.1186/s12885-018-4502-7
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