Panoramic view of MDH1: driving cancer progression and shaping the tumor immune microenvironment

BackgroundMalate dehydrogenase 1 (MDH1), an NAD(H)-dependent isoenzyme, is a key component of the malate-aspartate shuttle (MAS). A significant association has been observed between MDH1 expression and various characteristics of the tumor microenvironment across different cancer types.MethodsThis st...

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Bibliografische gegevens

Hoofdauteurs:	Yunchen Lou, Yunwei Lou, Yao Cheng, Beining Xu, Hanbin Chen, Yinwei Dai
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Frontiers Media S.A. 2025-08-01
Reeks:	Frontiers in Immunology
Onderwerpen:	single cell RNA-sequencing spatial transcriptomics lung adenocarcinoma macrophage glycolysis
Online toegang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1631449/full
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