The Active Subunit of the Cytolethal Distending Toxin, CdtB, Derived From Both Haemophilus ducreyi and Campylobacter jejuni Exhibits Potent Phosphatidylinositol-3,4,5-Triphosphate Phosphatase Activity

Human lymphocytes exposed to Aggregatibacter actinomycetemcomitans (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol (PI) 3,4,5-triphosphate phosphatase. Moreover, A...

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Principais autores:	Grace Huang, Kathleen Boesze-Battaglia, Lisa P. Walker, Ali Zekavat, Zachary P. Schaefer, Steven R. Blanke, Bruce J. Shenker
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-03-01
Colecção:	Frontiers in Cellular and Infection Microbiology
Assuntos:	cytolethal distending toxin host-parasite interactions lymphocytes toxins pathogenesis cell cycle arrest
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcimb.2021.664221/full
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