Innovative design and comprehensive characterization of a valine-enhanced lipid nanoparticle-coated mRNA vaccine targeting the SARS-CoV-2 S-RBD antigen

Abstract The SARS-CoV-2 pandemic has led to major advances in mRNA vaccine development. This study aimed to develop a cationic lipid nanoparticle (LNP) coated mRNA vaccine targeting the receptor binding domain (RBD) against the SARS-CoV-2 virus and adding valine to the N-terminal end to increase its...

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Principais autores:	Tugce Duran, Naci Cine, Mehmet Ali Karaselek, Nadir Gul, Serkan Kuccukturk, Durmus Hatipoglu, Mehmet Burak Ates, Umran Calıskan, Nadir Kocak
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-09-01
Serija:	Scientific Reports
Teme:	Vaccine Valine S-RBD Characterization
Online dostop:	https://doi.org/10.1038/s41598-025-08142-8
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