Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems

Abstract Advanced glycation endproducts (AGEs) are involved in several diseases, including NAFLD and NASH. RAGE is the main receptor mediating the pro-inflammatory signalling induced by AGEs. Therefore, targeting of RAGE has been proposed for prevention of chronic inflammatory diseases. However, the...

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Detalhes bibliográficos

Principais autores:	Kristiaan Wouters, Alessia S. Cento, Katrien H. Gaens, Margee Teunissen, Jean L. J. M. Scheijen, Federica Barutta, Fausto Chiazza, Debora Collotta, Manuela Aragno, Gabriella Gruden, Massimo Collino, Casper G. Schalkwijk, Raffaella Mastrocola
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2021-08-01
coleção:	Scientific Reports
Acesso em linha:	https://doi.org/10.1038/s41598-021-96859-7
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