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Mono-2-ethylhexyl phthalate-induced downregulation of MMP11 in foreskin fibroblasts contributes to the pathogenesis of hypospadias

Hypospadias is one of the most common congenital anomalies of the male urogenital system, and di(2-ethylhexyl) phthalate (DEHP), a widely used endocrine-disrupting chemical (EDC), is considered a significant risk factor for this condition. Mono-2-ethylhexyl phthalate (MEHP), the toxic active metabol...

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Principais autores: Youtian Zhang, Haixue Jia, Jiaming Fan, Jian Wang, Jianfeng Liu, Cuihong Yang, Yong Guan
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2024-10-01
coleção:Ecotoxicology and Environmental Safety
Assuntos:
MEHP
Hypospadias
Foreskin
Cell migration
Multiple transcriptomic profiling
DNA methylation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0147651324010649
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