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Simultaneously expressed miR-424 and miR-381 synergistically suppress the proliferation and survival of renal cancer cells---Cdc2 activity is up-regulated by targeting WEE1

OBJECTIVES: MiRNAs are intrinsic RNAs that interfere with protein translation. Few studies on the synergistic effects of miRNAs have been reported. Both miR-424 and miR-381 have been individually reported to be involved in carcinogenesis. They share a common putative target, WEE1, which is described...

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Principais autores: Binghai Chen, Lujing Duan, Guangming Yin, Jing Tan, Xianzhen Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier España 2013-06-01
Colecção:Clinics
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Acesso em linha:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322013000600825
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