Mitochondrial phosphoenolpyruvate carboxykinase promotes tumor growth in estrogen receptor‐positive breast cancer via regulation of the mTOR pathway

Abstract Background Tumor cells may aberrantly express metabolic enzymes to adapt to their environment for survival and growth. Targeting cancer‐specific metabolic enzymes is a potential therapeutic strategy. Phosphoenolpyruvate carboxykinase (PEPCK) catalyzes the conversion of oxaloacetate to phosp...

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Principais autores:	Hui‐Ping Hsu, Pei‐Yi Chu, Tsung‐Ming Chang, Kuo‐Wei Huang, Wen‐Chun Hung, Shih Sheng Jiang, Hui‐You Lin, Hui‐Jen Tsai
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2023-01-01
Series:	Cancer Medicine
Assuntos:	E2F1 estrogen receptor positive (ER+) breast cancer mitochondrial phosphoenolpyruvate carboxykinase (PEPCK‐M) mTORC1 PCK2
Acceso en liña:	https://doi.org/10.1002/cam4.4969
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