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Design of a peptide-based vaccine against human respiratory syncytial virus using a reverse vaccinology approach: evaluation of immunogenicity, antigenicity, allergenicity, and toxicity

BackgroundAttempts to develop an hRSV vaccine have faced safety and efficacy challenges, with only three FDA-approved vaccines (Moderna’s Mresvia, Pfizer’s Abrysvo, and GSK’s Arexvy) available. These vaccines are limited to individuals over 60 years, require boosters, and only reduce disease severit...

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Principais autores: Hadeel Alnajran, Maaweya Awadalla, Fahad M. Aldakheel, Intikhab Alam, Afaque A. Momin, Wael Alturaiki, Bandar Alosaimi
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-03-01
Serier:Frontiers in Immunology
Fag:
human respiratory syncytial virus
hRSV
immunoinformatics
CTL epitope
HTL epitope
B-cell epitope
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1546254/full
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