Adapting Neutralizing Antibodies to Viral Variants by Structure‐Guided Affinity Maturation Using Phage Display Technology

Abstract Neutralizing monoclonal antibodies have achieved great efficacy and safety for the treatment of numerous infectious diseases. However, their neutralization potency is often rapidly lost when the target antigen mutates. Instead of isolating new antibodies each time a pathogen variant arises,...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Frederik Peissert, Mattia Pedotti, Riccardo Corbellari, Luca Simonelli, Raoul De Gasparo, Elia Tamagnini, Louis Plüss, Abdullah Elsayed, Mattia Matasci, Roberto De Luca, Irene Cassaniti, Jose’ Camilla Sammartino, Antonio Piralla, Fausto Baldanti, Dario Neri, Luca Varani
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Wiley 2023-10-01
سلاسل:	Global Challenges
الموضوعات:	adapting antibodies to viral variants neutralizing antibodies structure‐guided affinity maturation
الوصول للمادة أونلاين:	https://doi.org/10.1002/gch2.202300088
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!