Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

The distribution and organisation of matrix molecules in the tumour stroma help shape solid tumour progression. Here they perform temporal proteomic profiling of the matrisome during breast cancer progression and show that collagen XII secreted from CAFs provides a pro-invasive microenvironment.

Bibliografiske detaljer

Principais autores:	Michael Papanicolaou, Amelia L. Parker, Michelle Yam, Elysse C. Filipe, Sunny Z. Wu, Jessica L. Chitty, Kaitlin Wyllie, Emmi Tran, Ellie Mok, Audrey Nadalini, Joanna N. Skhinas, Morghan C. Lucas, David Herrmann, Max Nobis, Brooke A. Pereira, Andrew M. K. Law, Lesley Castillo, Kendelle J. Murphy, Anaiis Zaratzian, Jordan F. Hastings, David R. Croucher, Elgene Lim, Brian G. Oliver, Fatima Valdes Mora, Benjamin L. Parker, David Gallego-Ortega, Alexander Swarbrick, Sandra O’Toole, Paul Timpson, Thomas R. Cox
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2022-08-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-022-32255-7
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!