Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation.

Mitochondrial function affects many aspects of cellular physiology, and, most recently, its role in epigenetics has been reported. Mechanistically, how mitochondrial function alters DNA methylation patterns in the nucleus remains ill defined. Using a cell culture model of induced mitochondrial DNA (...

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Principais autores:	Oswaldo A Lozoya, Inmaculada Martinez-Reyes, Tianyuan Wang, Dagoberto Grenet, Pierre Bushel, Jianying Li, Navdeep Chandel, Richard P Woychik, Janine H Santos
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2018-04-01
叢編:	PLoS Biology
在線閱讀:	http://europepmc.org/articles/PMC5927466?pdf=render
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