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A transcriptomic map of EGFR-induced epithelial-to-mesenchymal transition identifies prognostic and therapeutic targets for head and neck cancer

Abstract Background Epidermal growth factor receptor (EGFR) is both a driver oncogene and a therapeutic target in advanced head and neck squamous cell carcinoma (HNSCC). However, response to EGFR treatment is inconsistent and lacks markers for treatment prediction. This study investigated EGFR-induc...

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Principais autores: Henrik Schinke, Enxian Shi, Zhongyang Lin, Tanja Quadt, Gisela Kranz, Jiefu Zhou, Hongxia Wang, Julia Hess, Steffen Heuer, Claus Belka, Horst Zitzelsberger, Udo Schumacher, Sandra Genduso, Kristoffer Riecken, Yujing Gao, Zhengquan Wu, Christoph A. Reichel, Christoph Walz, Martin Canis, Kristian Unger, Philipp Baumeister, Min Pan, Olivier Gires
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-09-01
Serier:Molecular Cancer
Fag:
EGFR
ITGB4
EMT
HNSCC
EGFR-mediated invasion
Online adgang:https://doi.org/10.1186/s12943-022-01646-1
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