Thiosemicarbazones and selected tyrosine kinase inhibitors synergize in pediatric solid tumors: NDRG1 upregulation and impaired prosurvival signaling in neuroblastoma cells

Tyrosine kinase inhibitors (TKIs) are frequently used in combined therapy to enhance treatment efficacy and overcome drug resistance. The present study analyzed the effects of three inhibitors, sunitinib, gefitinib, and lapatinib, combined with iron-chelating agents, di-2-pyridylketone-4,4-dimethyl-...

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Bibliografski detalji

Glavni autori:	Maria Krchniakova, Silvia Paukovcekova, Petr Chlapek, Jakub Neradil, Jan Skoda, Renata Veselska
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2022-09-01
Serija:	Frontiers in Pharmacology
Teme:	pediatric solid tumors neuroblastoma tyrosine kinase inhibitors thiosemicarbazones receptor tyrosine kinases NDRG1
Online pristup:	https://www.frontiersin.org/articles/10.3389/fphar.2022.976955/full
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