From mechanism to clinical: research evolution and hotspot analysis of CD276/B7-H3 in cancer immunotherapy

BackgroundCD276 (B7-H3) is a pivotal immune checkpoint molecule with dual roles in T-cell regulation and tumor immune evasion, representing a promising therapeutic target across multiple cancers. However, a comprehensive analysis of the research landscape, evolutionary pathways, and knowledge struct...

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Bibliographic Details

Main Authors:	Chaojie Zhai, Jiarong Ye, Xiaoyan Li, Jipeng Liu, Xinchi Zhou, Zuao Wang, Xu Zhang, Wen Zeng, Hongliang Luo, Leifeng Chen, Fan Zhou
Format:	Artigo
Language:	Inglês
Published:	Frontiers Media S.A. 2026-04-01
Series:	Frontiers in Immunology
Subjects:	B7-H3 bibliometric analysis cancer immunotherapy CD276 immune checkpoint research trends
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1751400/full
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