Premedication with intranasal dexmedetomidine in patients undergoing total knee arthroplasty under spinal anaesthesia (TKADEX)—a prospective, double-blinded, randomised controlled trial

Background: Previous studies have shown that perioperative use of adjuvants, such as the alpha-2 agonist dexmedetomidine, may reduce postoperative pain and opioid requirements. However, information about optimal dosing is lacking. We investigated if premedication with intranasal dexmedetomidine comp...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Suvi-Maria Tiainen, Heta Heinonen, Atte Koskinen, Sanna Mäkelä, Ruut Laitio, Eliisa Löyttyniemi, Keijo Mäkelä, Teijo I. Saari, Panu Uusalo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-03-01
Schriftenreihe:	BJA Open
Schlagworte:	dexmedetomidine intranasal delivery multimodal analgesia nonopioid analgesics patient satisfaction premedication
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2772609625000061
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