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Efficacy and mechanism of energy metabolism dual-regulated nanoparticles (atovaquone-albendazole nanoparticles) against cystic echinococcosis

Abstract Background Albendazole (ABZ) and atovaquone (ATO) achieve killing efficacy on Echinococcus granulosus (Egs) by inhibiting energy metabolism, but their utilization rate is low. This study aims to analyze the killing efficacy of ABZ-ATO loading nanoparticles (ABZ-ATO NPs) on Egs. Methods Phys...

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Principais autores: Yuehong Gong, Tianjiao Zhou, Ruijia Ma, Jianhua Yang, Yicong Zhao, Meichi Pan, Zhangjian Huang, Hao Wen, Hulin Jiang, Jianhua Wang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-08-01
Serier:BMC Infectious Diseases
Fag:
Atovaquone-albendazole
Echinococcus Granulosus
Protoscolex
Nanoparticles
Cystic echinococcosis
Online adgang:https://doi.org/10.1186/s12879-024-09662-w
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