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Design and characterization of a protein fold switching network

In this work the authors investigate the structure-sequence dependance. The ability to design and characterize proteins at interfaces between three common folds suggests that fold switching is an intrinsic feature of protein folding language and likely important in the evolution of protein structure...

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Huvudupphov: Biao Ruan, Yanan He, Yingwei Chen, Eun Jung Choi, Yihong Chen, Dana Motabar, Tsega Solomon, Richard Simmerman, Thomas Kauffman, D. Travis Gallagher, John Orban, Philip N. Bryan
Materialtyp: Artigo
Språk:Inglês
Utgiven: Nature Portfolio 2023-01-01
Serie:Nature Communications
Länkar:https://doi.org/10.1038/s41467-023-36065-3
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