A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels

Resurgent currents (INaR) produced by voltage-gated sodium channels are required for many neurons to maintain high-frequency firing and contribute to neuronal hyperexcitability and disease pathophysiology. Here, we show, for the first time, that INaR can be reconstituted in a heterologous system by...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yucheng Xiao, Jonathan W Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R Cummins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2022-04-01
coleção:	eLife
Assuntos:	sodium channel resurgent currents FHF Navβ4 dorsal root ganglion
Acesso em linha:	https://elifesciences.org/articles/77558
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!