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Antagonism of the Thromboxane‐Prostanoid Receptor as a Potential Therapy for Cardiomyopathy of Muscular Dystrophy

Background Muscular dystrophy (MD) causes a progressive cardiomyopathy characterized by diffuse fibrosis, arrhythmia, heart failure, and early death. Activation of the thromboxane‐prostanoid receptor (TPr) increases calcium transients in cardiomyocytes and is proarrhythmic and profibrotic. We hypoth...

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Автори: James D. West, Cristi L. Galindo, Kyungsoo Kim, John Jonghyun Shin, James B. Atkinson, Ines Macias‐Perez, Leo Pavliv, Bjorn C. Knollmann, Jonathan H. Soslow, Larry W. Markham, Erica J. Carrier
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2019-11-01
Серія:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Предмети:
Duchenne muscular dystrophy cardiomyopathy
receptor blocker
TC receptor
Онлайн доступ:https://www.ahajournals.org/doi/10.1161/JAHA.118.011902
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