A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

Proper regulation of mTORC1 and mTORC2 upon nutrient starvation is critical for cancer cell survival. Upregulation of Sestrin2 in response to glutamine deprivation rescues cell death by suppressing mTORC1. However, the contribution of mTORC2 to Sestrin2-mediated mTORC1 suppression remains unclear. H...

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Bibliografski detalji

Glavni autori:	Jun-Kyu Byun, Yeon-Kyung Choi, Ji-Hyun Kim, Ji Yun Jeong, Hui-Jeon Jeon, Mi-Kyung Kim, Ilseon Hwang, Shin-Yup Lee, You Mie Lee, In-Kyu Lee, Keun-Gyu Park
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2017-07-01
Serija:	Cell Reports
Teme:	Sestrin 2 mTORC1 mTORC2 glutamine depletion
Online pristup:	http://www.sciencedirect.com/science/article/pii/S2211124717308975
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