Evidence-based successful example of a structure-based approach for the prediction of designer fentanyl-like molecules

In 2019, we published three innovative quantitative structure-activity relationship models (QSAR) for predicting the affinity of mu-opioid receptor (µOR) ligands. The three different models were then combined to produce a consensus model used to explore the chemical landscape of 3000 virtual fentany...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Giuseppe Floresta, Valeria Catalani, Vincenzo Abbate
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2024-12-01
Цуврал:	Emerging Trends in Drugs, Addictions, and Health
Нөхцлүүд:	QSAR Fentanyl µOR Opioid binding affinity Designer fentanyl-like molecules Novel synthetic opioids
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S2667118224000023
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!